Anwar Gill tallied 17 points and Jhamir Brickus added 13 points to lead La Salle (4-1), but the Explorers couldn't extend their best start in nine years.
La Salle coach Fran Dunphy was bidding for a milestone victory.
Filipowski, who sat out for some first-half stretches, scored the first eight Duke points of the second half.
The Blue Devils outscored La Salle 30-17 in the first 10 minutes of the second half.
Proctor had 10 points in the first 13 minutes and the Blue Devils went up 29-19 after his pair of 3-pointers.
Persons:
Rokas, Kyle Filipowski, Rob Kinnan, Tyrese, Sean Stewart, Mark Mitchell, Anwar Gill, Jhamir Brickus, Fran Dunphy, He's, Proctor, Filipowski, Duke, Jared McCain, TJ Power, La Salle's Khalil Brantley
Organizations:
La Salle Explorers, Duke Blue Devils, Cameron Indoor, Duke, La Salle, Blue Devils, Devils, Southern Indiana, Thomson
Locations:
Durham , North Carolina, USA, Durham, N.C, Saturday's